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Preanalytical variability in animals – a data base and search engine
modifier
Preanalytical variability in animals is a data base created in 2014 at the Veterinary School of Toulouse, France by the teaching group of Veterinary Clinical Pathology with the first aim to help students document possible errors on blood specimen collection and management for clinical pathology analyses. Then a search engine was developped in 2017 and updated in 2023[1] by a collaboration with the department of Biomathematics allowing to rapidly retrieve relevant information and its source in the aim to help veterinary practitionners and scientists in animal research centers
Constitution de la base de données
modifierSelection of collected information
modifierInformation collected was classified according to main catégories : 1/ name of biological variable; 2/ species; 3/ specimen analyzed; 4/ category of effect reported. As this data base deals with preanalytical variability[2], i.e the management of biological specimens for clinical pathology, no information was collected to factors of variation such as breed, age, sex which are partitioning factors of reference intervals[3][4].
The information was collected in textbbooks and mostly in original articles published in veterinary and other scientific journals, most of which are indexed in PubMed. There was no selection of the sources according to the quality of sources (eg impact factor) and results were reported as published.
Information is classified according to main catégories : 1/ name of biological variable; 2/ species; 3/ specimen analyzed; 4/ category of effect reported. As this data base deals with preanalytical variability, i.e the management of biological specimens for clinical pathology, no information was collected for factors of variation such as breed, age, sex which are partitioning factors of reference intervals[1, 2].
Structure of databases
modifierDatabases were created as Word tables with one line per an effect reported according to variable name/species/specimen/category of effect classification ; each line is associated to the complete reference of the source in cluded in the reference list of the database. Databases cover the whole range of animal species : domestic animals, laboratory animals, wild and zoo animals, from fish to mammals, and of specimens analyzed : blodd, urine, saliva, feces, hair, cerebrospinal fluid, etc. Moreover an introductory database reports review articles on preanalytical variability in animals.
In each data base, information is summarized as one or two lines for the effect reported, such as : Ammonium/Horse/Blood/Stability/●P(Hep): x~3 after 2d, x20 after 1wk at -20°C(Ogilvie et al. 1985)
Access to the information
modifierComplete databases (22 with more than 2200 references) can be freely downloaded from the website with a list of abbreviations available.
Specific information about a variable and/or a species and/or a specimen and or a type of effect can be selected by the search engine ; another possibility is to use one or several keywords. A report is displayed, which can be saved and/or printed; it includes the corresponding list of references. Unfortunately, due to copyright laws, the full text of the references, which is archived, is not available from the site and must be obtained from libraries or web sources.
- (en) ENVT, Crefre, Biostat, Bourdaud'hui P., « Preanalytical variability in animals, v2 » (consulté le )
- (en) Braun, J.P., N. Bourges-Abella, A. Geffre, D. Concordet, and C. Trumel,, « The preanalytic phase in veterinary clinical pathology. », Vet Clin Pathol, 2015;44(1): p. 8-25.
- (en) Geffre, A., K. Friedrichs, K. Harr, D. Concordet, C. Trumel, and J.P. Braun, « Reference values: A review », Veterinary Clinical Pathology, 2009;38(3): p. 288-298.
- (en) Friedrichs, K.R., K.E. Harr, K.P. Freeman, B. Szladovits, R.M. Walton, K.F. Barnhart, and J. Blanco-Chavez, « ASVCP reference interval guidelines: Determination of de novo reference intervals in veterinary species and other related topics », Vet Clin Pathol, 2012;41(4): p. 441-453