SMAD7

SMAD7
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ
Identifiants
Aliases	SMAD7
IDs externes	OMIM: 602932 MGI: 1100518 HomoloGene: 4314 GeneCards: SMAD7
Position du gène (Homme)
Chr.	Chromosome 18 humain
Fin	48,950,965 bp
Position du gène (Souris)
Chr.	Chromosome 18 (souris)
Fin	75,529,006 bp
Expression génétique
	Fortement exprimé dans
	artère poplitée; ; Veine saphène; ; aorte ascendante; ; poumon droit; ; artère coronaire gauche; ; artère coronaire droite; ; veine cave; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; upper lobe of left lung;
	Fortement exprimé dans
	molaire; ; left lung lobe; ; antre du pylore; ; cumulus cell; ; substantia nigra; ; sang; ; endocardial cushion; ; left colon; ; valve aortique; ; valve auriculo-ventriculaire;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison ADN; beta-catenin binding; type I transforming growth factor beta receptor binding; collagen binding; I-SMAD binding; activin binding; DNA-binding transcription factor activity; liaison ion métal; liaison protéique; ubiquitin protein ligase binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Composant cellulaire	cytoplasme; centrosome; transcription regulator complex; membrane plasmique; intracellulaire; nucléoplasme; catenin complex; noyau; fibrillar center; cytosol; complexe macromoléculaire;
Processus biologique	cellular response to transforming growth factor beta stimulus; regulation of ventricular cardiac muscle cell membrane depolarization; pathway-restricted SMAD protein phosphorylation; ureteric bud development; regulation of transcription, DNA-templated; adherens junction assembly; positive regulation of cell-cell adhesion; ventricular septum morphogenesis; regulation of epithelial to mesenchymal transition; negative regulation of peptidyl-threonine phosphorylation; negative regulation of transcription by competitive promoter binding; response to laminar fluid shear stress; protein stabilization; regulation of activin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; BMP signaling pathway; negative regulation of DNA-binding transcription factor activity; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of BMP signaling pathway; ventricular cardiac muscle tissue morphogenesis; negative regulation of protein ubiquitination; negative regulation of cell migration; negative regulation of ubiquitin-protein transferase activity; artery morphogenesis; negative regulation of peptidyl-serine phosphorylation; regulation of cardiac muscle contraction; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of epithelial to mesenchymal transition; positive regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-templated; transforming growth factor beta receptor signaling pathway; protein deubiquitination; negative regulation of T cell cytokine production; negative regulation of T-helper 17 type immune response; negative regulation of T-helper 17 cell differentiation; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologues
	4092
	17131
	ENSG00000101665
	ENSMUSG00000025880
	O15105
	O35253
	NM_005904; NM_001190821; NM_001190822; NM_001190823
	NM_001042660; NM_008543
	NP_001177750; NP_001177751; NP_001177752; NP_005895
	NP_001036125
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le SMAD7 (ou Mothers against decapentaplegic homolog 7) est une protéine dont le gène est SMAD7 situé sur le chromosome 18 humain.

Rôle modifier

Il inhibe le facteur de croissance transformant TGF-β1^[5].

Cible thérapeutique modifier

Le mongersen est un oligonucléotide se fixant sur l'ARN messager du SMAD7, facilitant sa dégradation. Donné par voie orale aux patients porteurs d'une maladie de Crohn, il en améliore les durées de rémission et les symptômes^[6].

Notes et références modifier

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000101665 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000025880 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT, Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease, J Clin Invest, 2001;108:601-609
↑ Monteleone G, Neurath MF, Ardizzone S et al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn’s disease, N Engl J Med, 2015;372:1104-1113

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000101665 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000025880 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Monteleone_2001-5] Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT, Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease, J Clin Invest, 2001;108:601-609

[Monteleone_2015-6] Monteleone G, Neurath MF, Ardizzone S et al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn’s disease, N Engl J Med, 2015;372:1104-1113

[1]

[2]

[3]

[4]

[5]

[6]