JAM3

JAM3
Identifiants
Aliases	JAM3, JAMC, JAM-C
IDs externes	OMIM: 606871 MGI: 1933825 HomoloGene: 11338 GeneCards: JAM3
Position du gène (Homme)
Chr.	Chromosome 11 humain
Fin	134,152,001 bp
Position du gène (Souris)
Chr.	Chromosome 9 (souris)
Fin	27,066,717 bp
Expression génétique
	Fortement exprimé dans
	corps calleux; ; ganglion inférieur du nerf vague; ; bulbe olfactif; ; globus pallidus; ; internal globus pallidus; ; external globus pallidus; ; Ganglion de Gasser; ; Veine saphène; ; noyau sous-thalamique; ; gyrus frontal moyen;
	Fortement exprimé dans
	nerf ischiatique; ; spermatocyte; ; cristallin; ; utricle; ; spermatide; ; Muscle oculomoteur; ; tube neural; ; medial ganglionic eminence; ; strie vasculaire; ; saccule;
	Plus de données d'expression de référence
	; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	protein homodimerization activity; integrin binding; liaison protéique; protein heterodimerization activity;
Composant cellulaire	integral component of membrane; membrane; cell-cell contact zone; jonction cellule-cellule; bicellular tight junction; membrane plasmique; desmosome; Incisures de Schmidt-Lanterman; région extracellulaire; jonction cellulaire; paranodal junction; milieu extracellulaire; appareil de Golgi; integral component of plasma membrane;
Processus biologique	neutrophil homeostasis; regulation of neutrophil chemotaxis; regulation of actin cytoskeleton organization by cell-cell adhesion; myeloid progenitor cell differentiation; adaptive immune response; axon regeneration; transmission of nerve impulse; leukocyte migration involved in inflammatory response; extracellular matrix organization; adhésion cellulaire; angiogenèse; spermatogenèse; establishment of cell polarity; spermatid development; myelination; cell-matrix adhesion; migration cellulaire; leukocyte migration; différenciation cellulaire;
	Sources:Amigo / QuickGO
Orthologues
	83700
	83964
	ENSG00000166086
	ENSMUSG00000031990
	Q9BX67
	Q9D8B7
	NM_032801; NM_001205329
	NM_023277
	NP_001192258; NP_116190
	NP_075766
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le JAM3 (pour « junctional adhesion molecule 3 »), aussi appelé JAMC ou JAM-C, est une protéine appartenant à la famille des JAM. Son gène est JAM3 situé sur le chromosome 11 humain.

Rôles modifier

Il interagit avec le JAM2, permettant la régulation de plusieurs types de lymphocytes^[5]. Il intervient également dans la spermatogenèse^[6]. Il permet la polarisation des cellules souches neuronales^[7] et joue un rôle dans le contrôle des cellules souches hématopoïétiques^[8].

Il interagit avec l'ITGAM au niveau plaquettaire^[9].

Il favorise la croissance tumorale^[10], la formation des métastases, en particulier lors d'un mélanome^[11] ou d'un lymphome^[12] et l'angiogenèse^[13]. De même, il contribue à la prolifération des cellules leucémiques^[14].

Notes et références modifier

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000166086 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000031990 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Liang TW, Chiu HH, Gurney A et al. Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3, J Immunol, 2002;168:1618–1626
↑ Gliki G, Ebnet K, Aurrand-Lions M, Imhof BA, Adams RH, Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C, Nature, 2004;431:320–324
↑ Stelzer S, Worlitzer MM, Bahnassawy L, JAM-C is an apical surface marker for neural stem cells, Stem Cells Dev, 2012;21:757–766
↑ Praetor A, McBride JM, Chiu H et al. Genetic deletion of JAM-C reveals a role in myeloid progenitor generation, Blood, 2009;113:1919–1928
↑ Santoso S, Orlova VV, Song K, Sachs UJ, Andrei-Selmer CL, Chavakis T, The homophilic binding of junctional adhesion molecule-C mediates tumor cell-endothelial cell interactions, J Biol Chem, 2005;280:36326–36333
↑ Leinster DA, Colom B, Whiteford JR et al. Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer, FASEB J, 2013;27:4244–4253
↑ Arcangeli ML, Frontera V, Bardin T et al. The Junctional Adhesion Molecule-B regulates JAM-C-dependent melanoma cell metastasis, FEBS Lett, 2012;586:4046–4051
↑ Doñate C, Ody C, McKee T, et al. Homing of human B cells to lymphoid organs and B-cell lymphoma engraftment are controlled by cell adhesion molecule JAM-C, Cancer Res, 2013;73:640–651
↑ Lamagna C, Hodivala-Dilke KM, Imhof BA, Aurrand-Lions M, Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth, Cancer Res, 2005;65:5703–5710
↑ Zhang Y, Xia F,Liu X et al. JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling, J Clin Invest, 2018;128:1737-1751

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000166086 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000031990 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Liang_2002-5] Liang TW, Chiu HH, Gurney A et al. Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3, J Immunol, 2002;168:1618–1626

[Gliki_2004-6] Gliki G, Ebnet K, Aurrand-Lions M, Imhof BA, Adams RH, Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C, Nature, 2004;431:320–324

[Stelzer_2012-7] Stelzer S, Worlitzer MM, Bahnassawy L, JAM-C is an apical surface marker for neural stem cells, Stem Cells Dev, 2012;21:757–766

[Praetor_2009-8] Praetor A, McBride JM, Chiu H et al. Genetic deletion of JAM-C reveals a role in myeloid progenitor generation, Blood, 2009;113:1919–1928

[Santoso_2005-9] Santoso S, Orlova VV, Song K, Sachs UJ, Andrei-Selmer CL, Chavakis T, The homophilic binding of junctional adhesion molecule-C mediates tumor cell-endothelial cell interactions, J Biol Chem, 2005;280:36326–36333

[Leinster_2013-10] Leinster DA, Colom B, Whiteford JR et al. Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer, FASEB J, 2013;27:4244–4253

[Arcangeli_2012-11] Arcangeli ML, Frontera V, Bardin T et al. The Junctional Adhesion Molecule-B regulates JAM-C-dependent melanoma cell metastasis, FEBS Lett, 2012;586:4046–4051

[Doñate_2013-12] Doñate C, Ody C, McKee T, et al. Homing of human B cells to lymphoid organs and B-cell lymphoma engraftment are controlled by cell adhesion molecule JAM-C, Cancer Res, 2013;73:640–651

[Lamagna_2005-13] Lamagna C, Hodivala-Dilke KM, Imhof BA, Aurrand-Lions M, Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth, Cancer Res, 2005;65:5703–5710

[Zhang_2018-14] Zhang Y, Xia F,Liu X et al. JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling, J Clin Invest, 2018;128:1737-1751

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