Micro-ARN 378

Le micro-ARN 378, ou miR-378, est un micro-ARN

Rôles modifier

Il est exprimé dans les cellules myocardiques^[1].

Il a une activité suppressive sur la voie de la MAPK (Mitogen-activated protein kinase) et permet d'inhiber la survenue d'une cardiomyopathie hypertrophique^[2]. Il protège de l'apoptose en cas d'ischémie en intervenant sur la caspase 3^[3]. Il inhibe également la voie de la protéine Ras^[1].

Le micro-ARN 378 semble intervenir sur l'expression de la néphronectine, favorisant une différenciation des ostéoblastes^[4].

Il interviendrait également sur le contrôle du métabolisme mitochondrial et sur l'homéostasie énergétique de l'organisme^[5].

HER2, une protéine intervenant dans différents cancers (dont celui du cancer du sein) semble réguler l'expression de ce microARN^[6]. Ce dernier pourrait favoriser la tumorogénèse et l'angiogenèse en jouant sur certaines protéines inhibitrices de tumeur^[7].

Notes et références modifier

↑ ^{a et b} Nagalingam RS, Sundaresan NR, Gupta MP, Geenen D, Solaro RJ, Gupta M, A cardiac enriched microRNA, miR-378 blocks cardiac hypertrophy by targeting Ras-signaling, J Biol Chem, 2013;288:11216–11232
↑ Ganesan J, Ramanujam D, Sassi Y et al. MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors, Circulation, 2013;127:2097–2106
↑ Fang J, Song XW, Tian J et al. Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes, Apoptosis, 2012;17:410–423
↑ Kahai S, Lee SC, Lee DY et al. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7, PLoS One, 2009;4:e7535
↑ Carrer M, Liu N, Grueter CE et al. Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*, Proc Natl Acad Sci U S A, 2012;109:15330–15335
↑ Eichner LJ, Perry M-C, Dufour CR et al. miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1beta/ERRgamma transcriptional pathway, Cell Metab, 2010;12:352–361
↑ Lee DY, Deng Z, Wang CH, Yang BB, MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression, Proc Natl Acad Sci U S A, 2007;104:20350–20355

[Nagalingam_2013-1] {a et b} Nagalingam RS, Sundaresan NR, Gupta MP, Geenen D, Solaro RJ, Gupta M, A cardiac enriched microRNA, miR-378 blocks cardiac hypertrophy by targeting Ras-signaling, J Biol Chem, 2013;288:11216–11232

[Ganesan_2013-2] Ganesan J, Ramanujam D, Sassi Y et al. MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors, Circulation, 2013;127:2097–2106

[Fang_2012-3] Fang J, Song XW, Tian J et al. Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes, Apoptosis, 2012;17:410–423

[Kahai_2009-4] Kahai S, Lee SC, Lee DY et al. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7, PLoS One, 2009;4:e7535

[Carrer_2012-5] Carrer M, Liu N, Grueter CE et al. Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*, Proc Natl Acad Sci U S A, 2012;109:15330–15335

[Eichner_20-6] Eichner LJ, Perry M-C, Dufour CR et al. miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1beta/ERRgamma transcriptional pathway, Cell Metab, 2010;12:352–361

[Lee_2007-7] Lee DY, Deng Z, Wang CH, Yang BB, MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression, Proc Natl Acad Sci U S A, 2007;104:20350–20355

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