PAX8

PAX8
	Structure de la protéine PAX8. Basé sur l'identifiant PDB 1k78.
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	2K27
Identifiants
Aliases	PAX8, Paired box gene 8
IDs externes	OMIM: 167415 MGI: 97492 HomoloGene: 2589 GeneCards: PAX8
Position du gène (Homme)
Chr.	Chromosome 2 humain
Fin	113,278,921 bp
Position du gène (Souris)
Chr.	Chromosome 2 (souris)
Fin	24,365,611 bp
Expression génétique
	Fortement exprimé dans
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right uterine tube; ; Médullaire rénale; ; rein; ; caput epididymis; ; corpus epididymis; ; muscle tibial antérieur; ; tubule rénal; ; nerf optique;
	Fortement exprimé dans
	thyroïde; ; proximal tubule; ; inner renal medulla; ; connecting tubule; ; rein; ; inner stripe of outer renal medulla; ; utérus; ; thin ascending limb of loop of Henle; ; Corne postérieure; ; capsule de Bowman;
	Plus de données d'expression de référence
	; ; ; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison ADN; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; thyroid-stimulating hormone receptor activity; liaison protéique; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Composant cellulaire	nucléoplasme; noyau;
Processus biologique	regulation of apoptotic process; pronephros development; regulation of metanephric nephron tubule epithelial cell differentiation; différenciation cellulaire; mesonephric tubule development; positive regulation of branching involved in ureteric bud morphogenesis; kidney epithelium development; regulation of transcription, DNA-templated; positive regulation of metanephric DCT cell differentiation; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis; negative regulation of apoptotic process involved in metanephric collecting duct development; kidney development; pronephric field specification; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; morphogenèse d'une structure anatomique; metanephric epithelium development; mesenchymal to epithelial transition involved in metanephros morphogenesis; transcription by RNA polymerase II; regulation of thyroid-stimulating hormone secretion; transcription, DNA-templated; otic vesicle development; metanephric distal convoluted tubule development; negative regulation of mesenchymal cell apoptotic process involved in metanephros development; mesonephros development; régulation positive de la transcription dépendante de l'ADN; metanephric nephron tubule formation; développent d'un organisme multicellulaire; central nervous system development; metanephric comma-shaped body morphogenesis; branching involved in ureteric bud morphogenesis; thyroid gland development; positive regulation of thyroid hormone generation; negative regulation of apoptotic process involved in metanephric nephron tubule development; S-shaped body morphogenesis; inner ear morphogenesis; urogenital system development; sulfur compound metabolic process; metanephric S-shaped body morphogenesis; metanephros development; cellular response to gonadotropin stimulus; positive regulation of transcription by RNA polymerase II; thyroid-stimulating hormone signaling pathway; negative regulation of cardiac muscle cell apoptotic process; ventricular septum development;
	Sources:Amigo / QuickGO
Orthologues
	7849
	18510
	ENSG00000125618
	ENSMUSG00000026976
	Q06710
	Q00288
	NM_003466; NM_013951; NM_013952; NM_013953; NM_013992
	NM_011040
	NP_003457; NP_039246; NP_039247; NP_054698
	NP_035170
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le PAX8 (pour « Paired box gene 8 ») est une protéine dont le gène, PAX8, est situé sur le chromosome 2 humain.

En médecine modifier

Il est exprimé dans les cellules rénales normales ainsi que dans presque totalité des tumeurs cancéreuses rénales (locales ou métastatiques), et dans une moindre proportion, en cas de tumeur à cellules claires^[5]. Sa recherche est ainsi un outil pour identifier l'origine d'une tumeur métastatique.

Notes et références modifier

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000125618 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000026976 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Barr ML, Jilaveanu LB, Camp RL, Adeniran AJ, Kluger HM, Shuch B, PAX-8 expression in renal tumours and distant sites: a useful marker of primary and metastatic renal cell carcinoma?, J Clin Pathol, 2015;68:12-17

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000125618 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000026976 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Barr_2015-5] Barr ML, Jilaveanu LB, Camp RL, Adeniran AJ, Kluger HM, Shuch B, PAX-8 expression in renal tumours and distant sites: a useful marker of primary and metastatic renal cell carcinoma?, J Clin Pathol, 2015;68:12-17

[1]

[2]

[3]

[4]

[5]