Mdm2

Le Mdm2 (pour « murine double minute 2 » est l'E3 ubiquitine ligase responsable de la régulation négative de p53. Son gène est le MDM2 situé sur le chromosome 12 humain est un oncogène.

MDM2
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS, 3G03, 3IUX, 3IWY, 3JZK, 3JZR, 3JZS, 3LBK, 3LBL, 3LNJ, 3LNZ, 3MQS, 3TJ2, 3TPX, 3TU1, 3V3B, 3VBG, 3VZV, 3W69, 4DIJ, 4ERE, 4ERF, 4HBM, 4HFZ, 4HG7, 4JV7, 4JV9, 4JVE, 4JVR, 4JWR, 4MDN, 4MDQ, 4OAS, 4OBA, 4OCC, 4ODE, 4ODF, 4OGN, 4OGT, 4OGV, 4OQ3, 4QO4, 4QOC, 4UMN, 4WT2, 4XXB, 4ZYC, 4ZYF, 4ZYI, 4UE1, 4UD7, 5AFG, 5HMI, 5HMK, 5HMH, 5C5A
Identifiants
Aliases	MDM2
IDs externes	OMIM: 164785 MGI: 96952 HomoloGene: 1793 GeneCards: MDM2
Position du gène (Homme) Chr. Chromosome 12 humain Locus 12q15 Début 68,808,177 bp Fin 68,845,544 bp
Position du gène (Souris) Chr. Chromosome 10 (souris) Locus 10 D2|10 66.32 cM Début 117,524,780 bp Fin 117,546,663 bp
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans tendon calcanéen right uterine tube nerf sural stromal cell of endometrium right lobe of liver éminence ganglionnaire body of pancreas poumon droit left adrenal gland thymus Fortement exprimé dans tube séminifère spermatocyte spermatide valve aortique secondary oocyte aorte ascendante thymus éminence ganglionnaire muscle long extenseur des orteils gyrus frontal supérieur Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire scaffold protein binding liaison protéique liaison enzymatique liaison ion métal identical protein binding ubiquitin protein ligase binding p53 binding SUMO transferase activity ubiquitin-protein transferase activity activité de transférase activité ligase 5S rRNA binding zinc ion binding ribonucleoprotein complex binding protein N-terminus binding ubiquitin protein ligase activity NEDD8 ligase activity disordered domain specific binding protein domain specific binding receptor serine/threonine kinase binding peroxisome proliferator activated receptor binding ubiquitin binding Composant cellulaire cytosol endocytic vesicle membrane membrane plasmique synapse corps nucléaire cytoplasme noyau nucléoplasme nucléole complexe macromoléculaire Processus biologique negative regulation of signal transduction by p53 class mediator endocardial cushion morphogenesis cellular response to UV-C atrial septum development regulation of heart rate DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of gene expression blood vessel development positive regulation of cell population proliferation negative regulation of DNA damage response, signal transduction by p53 class mediator response to ether blood vessel remodeling cellular response to hypoxia heart valve development cellular response to estrogen stimulus negative regulation of apoptotic process cellular response to organic substance cellular response to hydrogen peroxide response to cocaine cardiac septum morphogenesis negative regulation of transcription by RNA polymerase II peptidyl-lysine modification positive regulation of cell cycle ventricular septum development positive regulation of protein export from nucleus response to steroid hormone cellular response to growth factor stimulus regulation of protein catabolic process cellular response to antibiotic negative regulation of gene expression positive regulation of mitotic cell cycle développement du cœur cellular response to alkaloid cellular response to vitamin B1 response to magnesium ion negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to peptide hormone stimulus cellular response to organic cyclic compound viral process response to iron ion régulation de l'expression des gènes response to antibiotic traversing start control point of mitotic cell cycle Ubiquitination negative regulation of protein processing establishment of protein localization réponse à une substance toxique response to morphine atrioventricular valve morphogenesis protein localization to nucleus regulation of signal transduction by p53 class mediator positive regulation of vascular associated smooth muscle cell proliferation response to water-immersion restraint stress negative regulation of neuron projection development positive regulation of vascular associated smooth muscle cell migration protein deubiquitination Sumoylation transcription factor catabolic process protein autoubiquitination response to formaldehyde protein destabilization negative regulation of transcription, DNA-templated proteolysis involved in cellular protein catabolic process cellular response to gamma radiation cellular response to actinomycin D negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator formation de fibrilles amyloïdes protein-containing complex assembly ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 4193 17246 Ensembl ENSG00000135679 ENSMUSG00000020184 UniProt Q00987 P23804 RefSeq (mRNA) NM_001145336 NM_001145337 NM_001145339 NM_001145340 NM_001278462 NM_002392 NM_006878 NM_006879 NM_006880 NM_006881 NM_006882 NM_032739 NM_001367990 NM_001288586 NM_010786 RefSeq (protéine) NP_001138809 NP_001138811 NP_001138812 NP_001265391 NP_002383 NP_001354919 NP_001275515 NP_034916 Localisation (UCSC) Chr 12: 68.81 – 68.85 Mb Chr 10: 117.52 – 117.55 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

C'est une protéine qui est retrouvée chez l'humain. Elle va ubiquitiniler la protéine p53 (gardienne du génome) et ce faisant, p53 sera dégradé par le complexe du protéasome sans exercer son effet. Une mutation amplificatrice de MDM2 inactive complètement p53 donc les dégâts de l'ADN n'entraineront plus de réparation cellulaire ou d'apoptose ce qui va donner naissance à un cancer.

Voir aussi

• MDM4, protéine de rôle proche
• Chromosome minuscule double