IQGAP1

IQGAP1
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1X0H, 2RR8, 3FAY, 3I6X
Identifiants
Aliases	IQGAP1
IDs externes	OMIM: 603379 MGI: 1352757 HomoloGene: 74514 GeneCards: IQGAP1
Position du gène (Homme)
Chr.	Chromosome 15 humain
Fin	90,502,239 bp
Position du gène (Souris)
Chr.	Chromosome 7 (souris)
Fin	80,475,722 bp
Expression génétique
	Fortement exprimé dans
	tendon calcanéen; ; monocyte; ; artère coronaire droite; ; secondary oocyte; ; lobe inférieur du poumon; ; artère poplitée; ; aorte ascendante; ; artère coronaire gauche; ; vagin; ; sang;
	Fortement exprimé dans
	left lung lobe; ; lobe pulmonaire droit; ; left colon; ; strie vasculaire; ; corneal stroma; ; conjunctival fornix; ; corpuscule carotidien; ; cordon ombilical; ; medullary collecting duct; ; calvaria;
	Plus de données d'expression de référence
	; ; ; ;
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	Calcium liaison ionique; S100 protein binding; protein domain specific binding; liaison de complexe macromoléculaire; protein serine/threonine kinase activator activity; GTPase inhibitor activity; liaison protéique; protein phosphatase binding; protein kinase binding; phosphatidylinositol-3,4,5-trisphosphate binding; GTPase activator activity; mitogen-activated protein kinase binding; cadherin binding; fixation de la calmoduline; small GTPase binding; molecular adaptor activity;
Composant cellulaire	cytoplasme; cytosol; lateral plasma membrane; jonction cellule-cellule; membrane; microtubule cytoskeleton; cône de croissance; ruffle; extrinsic component of cytoplasmic side of plasma membrane; membrane plasmique; slit diaphragm; axone; midbody; cell leading edge; filament d'actine; actin cytosquelette; neuron projection; cytoplasmic ribonucleoprotein granule; microtubule; exosome; radeau lipidique; noyau; focal adhesion; secretory granule membrane; complexe macromoléculaire; Ribonucléoprotéine;
Processus biologique	cellular response to calcium ion; glomerular visceral epithelial cell development; epidermal growth factor receptor signaling pathway; negative regulation of dephosphorylation; regulation of GTPase activity; cellular response to platelet-derived growth factor stimulus; cellular response to fibroblast growth factor stimulus; neuron projection extension; cellular response to epidermal growth factor stimulus; regulation of cytokine production; fibroblast growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; transduction de signal; positive regulation of protein kinase activity; positive regulation of focal adhesion assembly; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of GTPase activity; positive regulation of protein localization; positive regulation of dendrite development; positive regulation of MAP kinase activity; positive regulation of vascular associated smooth muscle cell migration; negative regulation of GTPase activity; response to angiotensin; neutrophil degranulation; regulation of mitotic cell cycle; migration cellulaire; viral process;
	Sources:Amigo / QuickGO
Orthologues
	8826
	29875
	ENSG00000140575
	ENSMUSG00000030536
	P46940
	Q9JKF1
	NM_003870
	NM_016721
	NP_003861
	NP_057930
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

IQGAP1 est une protéine d'échafaudage (participant à la transduction de signaux entre cellules en régulant l’activation des cascades moléculaires impliqués dans la transmission du signal) dont le gène est IQGAP1 situé sur le chromosome 15 humain.

Rôles modifier

Elle se fixe à l'actine et jouerait un rôle dans la formation des filaments d'actine^[5].

Elle se fixe également sur l'ERK2^[6], sur le MAPK^[7] (« mitogen-activated protein kinase »), sur le CDC42 (« Cell division control protein 42 »), le RAC1^[8], la calmoduline^[9] et en régule les activités.

Par son action, elle semble jouer un rôle dans de nombreuses maladies, cancer^[10] ou asthme^[11] par exemple.

Notes et références modifier

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000140575 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000030536 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Brandt DT, Grosse R, Get to grips: steering local actin dynamics with IQGAPs, EMBO Rep, 2007;8:1019–1023
↑ Roy M, Li Z, Sacks DB, IQGAP1 binds ERK2 and modulates its activity, J Biol Chem, 2004;279:17329–17337
↑ Roy M, Li Z, Sacks DB, IQGAP1 is a scaffold for mitogen-activated protein kinase signaling, Mol Cell Biol, 2005;25:7940–7952
↑ Kuroda S, Fukata M, Nakagawa M et al. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion, Science, 1998;281:832–835
↑ Hart MJ, Callow MG, Souza B, Polakis P, IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs, EMBO J, 1996;15:2997–3005
↑ Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB, Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration, J Biol Chem, 2012;287:38367–3878
↑ Bhattacharya M, Sundaram A, Kudo M, IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction, J Clin Invest, 2014;124:4895–4898

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000140575 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000030536 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[5] Brandt DT, Grosse R, Get to grips: steering local actin dynamics with IQGAPs, EMBO Rep, 2007;8:1019–1023

[6] Roy M, Li Z, Sacks DB, IQGAP1 binds ERK2 and modulates its activity, J Biol Chem, 2004;279:17329–17337

[7] Roy M, Li Z, Sacks DB, IQGAP1 is a scaffold for mitogen-activated protein kinase signaling, Mol Cell Biol, 2005;25:7940–7952

[8] Kuroda S, Fukata M, Nakagawa M et al. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion, Science, 1998;281:832–835

[9] Hart MJ, Callow MG, Souza B, Polakis P, IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs, EMBO J, 1996;15:2997–3005

[10] Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB, Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration, J Biol Chem, 2012;287:38367–3878

[11] Bhattacharya M, Sundaram A, Kudo M, IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction, J Clin Invest, 2014;124:4895–4898

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]